MICL (CLEC12A, C-type Lectin Domain Family 12 Member A , CLL-1, C-type Lectin-like Molecule-1, DCAL-2, KLRL1, Killer Cell Lectin-like Receptor) (PerCP)

MICL, also known as C-type lectin-like molecule-1 (CLL-1), killer cell lectin-like receptor (KLRL1), and C-type lectin domain family 12 member A (CLEC12A), is a highly glycosylated, type II transmembrane protein that contains a functional tyrosine-based inhibitory motif in its cytoplasmic tail. The gene for MICL has been mapped to the natural killer gene complex (NKC) on human chromosome 12p13.2. MICL contains a non-classic C-type domain that binds non-sugar ligands. It is primarily expressed on natural killer (NK) cells, T cells, dendritic cells, monocytes, and macrophages. By alternative splicing, multiple splice isoforms exist. MICL is a negative regulator of granulocytes and monocyte function and inhibits NK cell cytotoxicity. The amino acid sequence of the human MICL extracellular domain is 53%, 65%, and 55% identical to that of mouse, canine, and bovine MICL, respectively.\n\nApplications: \nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: 10ul, 1x10e6 cells\nOptimal dilutions to be determined by the researcher.\n\nHybridoma: \nMouse myeloma cells with B cells from Balb/c mice.\n\nStorage and Stability:\nMay be stored at 4 degrees C. For long-term storage, aliquot and store at 4 degrees C. Do not freeze. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. PerCP conjugates are sensitive to light.

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