Home  >  Products  >  MIM1 (4-(E)-[[(2Z)-2-cyclohexylimino)-4-m ethyl-1,3-thiazol-3(2H)-yl]imino]methyl]benzene-1, 2,3-triol)
MIM1 (4-(E)-[[(2Z)-2-cyclohexylimino)-4-m ethyl-1,3-thiazol-3(2H)-yl]imino]methyl]benzene-1, 2,3-triol)

MIM1 (4-(E)-[[(2Z)-2-cyclohexylimino)-4-m ethyl-1,3-thiazol-3(2H)-yl]imino]methyl]benzene-1, 2,3-triol)

Cat no: 167681

Supplier: United States Biological
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Solubility: 100mM in DMSO and 20mM in ethanol Molecular Formula: C17H21N3O3S Biological Activity: Inhibitor of Mcl-1; selectively targets the BH3-binding pocket. Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 167681
Size: 10mg
Form: Supplied as a solid.
References: 1. Cohen et al (2012) A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem.Biol. 19 1175. PMID: 22999885.

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