MIP-1b, Recombinant, Rat (Macrophage Inflammatory Protein-1beta, CCL4, ACT-2)

Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines.They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells.While both MIP-1alpha and MIP-1beta exert similar effects on monocytes their effect on lymphocytes differ with MIP-1alpha selectively attracting CD8+ lymphocytes and MIP-1beta selectively attracting CD4+ lymphocytes.Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells.Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells.Recombinant rat MIP-1beta is a 7.8kD protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.\n\nBiological Activity:\nDetermined by its ability to chemoattract human monocytes using a concentration range of 0.01-1.0ug/ml.\n\nAA Sequence:\nAPIGSDPPTS CCFSYTSRKI HRNFVMDYYE TSSLCSQPAV VFLTKKGRQI CADPSEPWVN EYVNDLELN\n\nCrossreactivity:\nHuman\n\nQuality Control:\nVerified by N-terminal and Mass Spectrometry analyses (when applicable).\n\nEndotoxin:\n<0.1ng/ug of protein (<1EU/ug).\n\nProtein Content:\nVerified by UV Spectroscopy and/or SDS-PAGE gel.\n\nStorage and Stability:\nStore lyophilized products at -20 degrees C. For reconstituted solutions of most products, we recommend short-term storage at 4 degrees C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20 degrees C. Additional freeze/thaw cycles may cause some denaturation of the protein.

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