Home  >  Products  >  MMAB, aa33-250, Recombinant, Human (Cob(I)yrinic Acid a,c-diamide Adenosyltransferase, Mitochondrial, Cob(I)alamin Adenosyltransferase, Methylmalonic Aciduria Type B Protein)

MMAB, aa33-250, Recombinant, Human (Cob(I)yrinic Acid a,c-diamide Adenosyltransferase, Mitochondrial, Cob(I)alamin Adenosyltransferase, Methylmalonic Aciduria Type B Protein)

Cat no: M4024-05


Supplier: United States Biological
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MMAB is a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12 containing coenzyme for methylmalonyl-CoA mutase(MCM). Impaired MMAB activity leads to the inherited disorder vitamin B12 dependent methylmalonic aciduria linked to the cblB complementation group. Source: Recombinant corresponding to aa33-250 of human MMAB protein, fused to His-tag at N-terminus, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MQSRGPQGVE DGDRPQPSSK TPRIPKIYTK TGDKGFSSTF TGERRPKDDQ VFEAVGTTDE LSSAIGFALE LVTEKGHTFA EELQKIQCTL QDVGSALATP CSSAREAHLK YTTFKAGPIL ELEQWIDKYT SQLPPLTAFI LPSGGKISSA LHFCRAVCRR AERRVVPLVQ MGETDANVAK FLNRLSDYLF TLARYAAMKE GNQEKIYKKN DPSAESEGL Molecular Weight: 26.3kD (239aa), confirmed by MALDI-TOF Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: M4024-05
Size: 100ug
Form: Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 10% glycerol.
Purity: ~95% (SDS-PAGE).
References: 1. Gravel RA., et al. (2009) Mol Genet Metab. 98(3):278-84. 2. Edwards AM., et al (2004) J Biol Chem. 279(22):23646-53.

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