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MOBKL1B, NT (MOB1A, C2orf6, MOB4B, MOBK1B, MOBKL1B, MOB kinase activator 1A, Mob1 alpha, Mob1 homolog 1B, Mps one binder kinase activator-like 1B)

Cat no: 038524

MOBKL1B, NT (MOB1A, C2orf6, MOB4B, MOBK1B, MOBKL1B, MOB kinase activator 1A, Mob1 alpha, Mob1 homolog 1B, Mps one binder kinase activator-like 1B)

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L.\n\nApplications:\nSuitable for use in Western Blot, Flow Cytometry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:50-100\nFlow Cytometry: 1:10-50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

038524

Size

200ul

Applications

ELISA, FC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Pab

Purity

Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.

Isotype

IgG

References

Chow, A., et al. Int. J. Cancer 126(9):2079-2089(2010)\nWilmeth, L.J., et al. Mol. Biol. Cell 21(3):380-392(2010)\nKosaka, Y., et al. Int. J. Oncol. 31(2):333-338(2007)\nLamesch, P., et al. Genomics 89(3):307-315(2007)\nEwing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

Additional Info

Human

Alternative Names

MOB1A, C2orf6, MOB4B, MOBK1B, MOBKL1B, MOB kinase activator 1A, Mob1 alpha, Mob1 homolog 1B, Mps one binder kinase activator-like 1B

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