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Moesin, Recombinant, Human (MSN, Membrane-organizing Extension Spike Protein)

Cat no: M4300-02

Moesin, Recombinant, Human (MSN, Membrane-organizing Extension Spike Protein)

Moesin (for membrane-organizing extension spike protein) is a member of the ERM protein family which includes ezrin and radixin. The ERM proteins have a crucial role in organizing membrane domains through their ability to interact with transmembrane proteins and the cytoskeleton. The C-terminal domain may form an intramolecular band to the N-terminal four-point-one ERM homology domain or may bind to F-actin depending on the phosphorylation state of a conserved threonine residue (Thr567 in ezrin, Thr564 in radixin, and Thr558 in moesin). An essential role of the 78kD protein Moesin is described for Rho- and Rac-dependent assembly of actin filaments.\n\nSource:\nRecombinant corresponding to aa1-577 from human Moesin, fused to N-His tag expressed in E.coli.\n\nMolecular Weight:\n~70kD\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

M4300-02

Size

200ug

Form

Supplied as a lyophilized powder from 20mM HEPES, pH7.0.

Purity

~95% (SDS-PAGE)

References

1. Rudiger Blindta et al., 2002, Cardiovascular Research 54:630-639. 2. Xiaohua Guo et al.,Am J Physiol Heart Circ Physiol , 2009, 297: H238-H246.

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Applications

ELISA

Reactivities

Hum

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Applications

IF

Hosts

Mouse

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Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

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Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info
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