MOG, Recombinant, Rat, aa1-125 (Myelin-oligodendrocyte Glycoprotein)

Myelin Oligodendrocyte Glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in central nervous system (CNS). Although MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins, it was demonstrated that MOG protein is a crucial autoantigen for multiple sclerosis in humans and experimental autoimmune encephalomyelitis (EAE) in rodents and monkeys. The purified rat rMOG is recommended for in vitro studies such as T cell and B cell responses, cytokine response, antigen presentation, Western blotting, and ELISA as well as for in vivo study such as EAE induction in rats. The following dosages are recommended: 5-20ug/ml for in vitro study and 50ug per animal for in vivo study.\n\nSource:\nRecombinant corresponding to the extracellular domain of rat MOG, 6x His tag, expressed in E. coli.\n\nMolecular Weight:\n~14.2kD\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

M9758-12C

Size

100ug

Form

Supplied as a liquid in 20mM sodium acetate buffer, pH 4.0.

Purity

~95% (SDS-PAGE)

References

1. Jayaram Bettadapura et.al. (1998) Journal of Neurochemistry 70 (4): 1593-1599. 2. Alfred R Oliver et al (2003) Journal of Immunology 171:462-468. 3. Hans-Christian Von Budingen et.al. (2001) Journal of Clinical Immunology 21 (3): 155-170. 4. Jerri-Anne Lyons et.al. (1999) European Journal of Immunology 29: 3432-3439. 5. Hans-Christian Von Budingen et.al. (2004) European Journal of Immunology 34: 2072-2083.