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Monactin (5-demethyl-5-ethylnonactin, Antibiotic AKD 1B)

Cat no: M4431


Supplier: United States Biological
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Monactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. Unlike nonactin, monactin has not previously been available for intensive investigation. Early literature reported that the related dinactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Monactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-gamma. Purity: >95% by HPLC Solubility: Soluble in ethyl acetate or DMSO, moderately in soluble ethanol or methanol. Related to: Dinactin, Trinactin
Catalogue number: M4431
Size: 1mg
Purity: >95% by HPLC
Alternative names: 5-demethyl-5-ethylnonactin, Antibiotic AKD 1B
References: 1. Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation. Umland S.P. et al. Am. J. Respir. Cell Mol. Biol. 1999, 20, 481. 2. Immunosuppressive effects of polynactins (tetranactin, trinactin and dinactin) on experimental autoimmune uveoretinitis in rats. Tanouchi Y. et al. Jpn. J. Ophthalmol. 1987, 31, 218. 3. Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Graven S.N. et al. Biochemistry 1966, 5, 1735.

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