Monactin (5-demethyl-5-ethylnonactin, Antibiotic AKD 1B)

Monactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. Unlike nonactin, monactin has not previously been available for intensive investigation. Early literature reported that the related dinactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Monactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-gamma.\n\nPurity: >95% by HPLC\n\nSolubility: Soluble in ethyl acetate or DMSO, moderately in soluble ethanol or methanol.\n\nRelated to: Dinactin, Trinactin

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SPECIFICATIONS

Catalog Number

M4431

Size

1mg

Purity

>95% by HPLC\n\n

References

1. Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine \npulmonary inflammation. Umland S.P. et al. Am. J. Respir. Cell Mol. Biol. 1999, 20, 481. \n2. Immunosuppressive effects of polynactins (tetranactin, trinactin and dinactin) on experimental \nautoimmune uveoretinitis in rats. Tanouchi Y. et al. Jpn. J. Ophthalmol. 1987, 31, 218. \n3. Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by \nnonactin, monactin, dinactin, and trinactin. Graven S.N. et al. Biochemistry 1966, 5, 1735.

Alternative Names

5-demethyl-5-ethylnonactin, Antibiotic AKD 1B