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Mouse Anti-Human ADORA2A monoclonal antibody, clone WNB11191

Cat no: CABT-L1968

Mouse Anti-Human ADORA2A monoclonal antibody, clone WNB11191

Mouse Anti-Human ADORA2A monoclonal antibody for WB. Adenosine receptor A2A is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. Adenosine receptor of A2A subtype uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.

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SPECIFICATIONS

Catalog Number

CABT-L1968

Hosts

Mouse

Reactivities

Hum

Conjugates

Unconj

Clone

WNB11191

Target

ADORA2A

Gene Id

135

Isotype

IgG1

Clonality

Monoclonal

Storage Temp

Store undiluted at -20В°C, avoiding repeated freeze thaw cycles.

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