Mouse Anti-Human CD73 monoclonal antibody, clone 717223

Mouse Anti-Human CD73 monoclonal antibody for FC. 5'-Nucleotidase (also [ecto]-5'-nucleotidase/5'-NT, designated CD73) is a variably glycosylated, 69-73 kDa member of the 5'-Nucleotidase family of enzymes. It is expressed on multiple cell types, including vascular endothelium, transitional and nonkeratinized epithelium, cardiomyocytes, small intestine epithelium, FoxP3+ Treg lymphocytes, FDCs and B cells. 5'-Nucleotidase hydrolyzes AMP to adenosine and phosphate. This creates diffusible nucleosides necessary for cell homeostasis, and a ligand for cell membrane adenosine receptors. Mature human 5'-Nucleotidase is a 523 amino acid (aa) GPI-linked protein (aa 27-549). It contains a large Zn?dependent nucleotidase catalytic region (aa 28-532) and a C-terminal substrate binding site (aa 500-506). On the cell surface it exists as a disulfide-linked homodimer. Two splice variants are reported. One shows a deletion of aa 405-454, and a second possesses a 12 aa substitution for aa 253-574. Over aa 1-511, human 5'?Nucleotidase shares 88% aa identity with both mouse and rat 5'-Nucleotidase.

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SPECIFICATIONS

Catalog Number

CABT-L1980

Hosts

Mouse

Reactivities

Hum

Conjugates

Unconj

Clone

717223

Target

NT5E

Gene Id

4907

Isotype

IgG2b

Clonality

Monoclonal

Storage Temp

se a manual defrost freezer and avoid repeated freeze-thaw cycles.<br/>12 months from date of receipt, -20 to -70 В°C as supplied.<br/>1 month, 2 to 8 В°C under sterile conditions after reconstitution.<br/>6 months, -20 to -70 В°C under sterile conditions after reconstitution.<br/>Background: 5'-Nucleotidase/CD73