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Mouse Anti-Human CD73 monoclonal antibody, clone 717223

Mouse Anti-Human CD73 monoclonal antibody, clone 717223

Cat no: CABT-L1980

Supplier: Creative Diagnostics
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Mouse Anti-Human CD73 monoclonal antibody for FC. 5'-Nucleotidase (also [ecto]-5'-nucleotidase/5'-NT, designated CD73) is a variably glycosylated, 69-73 kDa member of the 5'-Nucleotidase family of enzymes. It is expressed on multiple cell types, including vascular endothelium, transitional and nonkeratinized epithelium, cardiomyocytes, small intestine epithelium, FoxP3+ Treg lymphocytes, FDCs and B cells. 5'-Nucleotidase hydrolyzes AMP to adenosine and phosphate. This creates diffusible nucleosides necessary for cell homeostasis, and a ligand for cell membrane adenosine receptors. Mature human 5'-Nucleotidase is a 523 amino acid (aa) GPI-linked protein (aa 27-549). It contains a large Zn?dependent nucleotidase catalytic region (aa 28-532) and a C-terminal substrate binding site (aa 500-506). On the cell surface it exists as a disulfide-linked homodimer. Two splice variants are reported. One shows a deletion of aa 405-454, and a second possesses a 12 aa substitution for aa 253-574. Over aa 1-511, human 5'?Nucleotidase shares 88% aa identity with both mouse and rat 5'-Nucleotidase.
Catalogue number: CABT-L1980
Reactivities: Human
Hosts: Mouse
Conjugates: Unconjugated
Clone: 717223
Gene: 4907
Target: NT5E
Isotype: IgG2b
Clonality: Monoclonal
Storage temp: se a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: 5'-Nucleotidase/CD73

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