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Mouse Anti-Human IGFBP4 monoclonal antibody, clone JCQ293

Cat no: DMAB-L21049

Mouse Anti-Human IGFBP4 monoclonal antibody, clone JCQ293

Mouse Anti-Human IGFBP4 monoclonal antibody for ELISA(Cap), ELISA(Det). Human IGF binding protein 4 (IGFBP-4) was isolated from human plasma based on its ability to bind immobilized IGF-I. Human IGFBP-4 cDNA encodes a 258 amino acid (aa) residue precursor protein with a predicted 21 aa residue signal peptide that is processed to generate the 237 aa residue mature human IGFBP-4. The human IGFBP-4 contains a potential N-linked glycosylation site and shares approximately 90% amino acid sequence identity with both the mouse and rat IGFBP-4. According to the nomenclature of IGFBPs defined at the 4th International Symposium of IGFs, six high-affinity IGF binding proteins (IGFBP-1, -2, -3, 4, -5, -6), and four IGFBP-related proteins (IGFBPr-1, - 2, -3, -4) have been identified. All IGFBPs have a high cysteine content and share conserved cysteine residues that are clustered in the amino- and carboxy-terminal third of the molecule. IGFBPs have been shown to either inhibit or enhance the biological activities of IGF, or act in an IGF-independent manner. Post-translational modification of IGFBPs, including phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins for IGF and may indirectly regulate IGF actions.

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SPECIFICATIONS

Catalog Number

DMAB-L21049

Hosts

Mouse

Reactivities

Hum

Conjugates

Unconj

Clone

JCQ293

Target

IGFBG4

Isotype

IgG2b

Clonality

Monoclonal

Storage Temp

Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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