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Mouse anti Human IL18 monoclonal antibody, clone 236-3I

Cat no: CABT-L204

Mouse anti Human IL18 monoclonal antibody, clone 236-3I

Mouse Anti-Human IL18 monoclonal antibody for ELISA(Cap), IP. Interleukin 18 (IL-18) is a 18 kDa cytokine which identified as a costimulatory factor for production of interferon-gamma(IFN-gamma) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24 kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-gamma is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN-gamma activates macrophages, enhances NK activity and B cell maturation, proliferation and Ig secretion, induces MHC class I and II antigens, and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-gamma. Pleiotropic effects of IL-18 has also been reported, such as, enhancement production of IFN-gamma and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF and IFN-gamma in T cells, enhancement of Fas ligand expression by Th1 cells.

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SPECIFICATIONS

Catalog Number

CABT-L204

Hosts

Mouse

Reactivities

Hum

Conjugates

Unconj

Clone

236-3I

Target

IL18

Gene Id

3606

Isotype

IgG1

Clonality

Monoclonal

Storage Temp

This antibody solution is stable for one year from the date of purchase when stored at-20В°C.

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