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Mouse anti Human IL1RN monoclonal antibody, clone 21410

Mouse anti Human IL1RN monoclonal antibody, clone 21410

Cat no: CABT-L205

Supplier: Creative Diagnostics
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Mouse Anti-Human IL1RN monoclonal antibody for ELISA(Cap). IL-1ra was originally isolated from the urine of patients with monocytic leukemia and has also been purified from adherent monocytes. The naturally occurring, fully glycosylated form has an apparent molecular weight of about 25,000 Daltons. The protein shows 26% amino acid homology to IL-1 beta b and 19% homology to IL-1 alpha. It will compete with either factor for receptor binding, but does not interact with either one. Human IL-1ra will bind to both types of IL-1 receptor (I and II) on human cells, but reportedly will not block binding to the type II receptor on murine pre-B cell lines. The recombinant, non-glycosylated form of IL-1ra blocks binding of IL-1 to its receptor equally as well as the naturally-occurring, glycosylated form. The IL-1ra has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo. Currently, pre-clinical and clinical studies are underway to test possible therapeutic applications for IL-1ra in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia.
Catalogue number: CABT-L205
Reactivities: Human
Hosts: Mouse
Conjugates: Unconjugated
Clone: 21410
Gene: 3557
Target: IL1RN
Isotype: IgG2A
Clonality: Monoclonal
Storage temp: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

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