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Mouse Anti-Human PML (aa 411-510) monoclonal antibody

Cat no: CABT-L952

Mouse Anti-Human PML (aa 411-510) monoclonal antibody

Mouse Anti-Human PML (aa.411-510) monoclonal antibody for WB, IF, ELISA. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

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SPECIFICATIONS

Catalog Number

CABT-L952

Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Rat

Conjugates

Unconj

Target

PML

Gene Id

5371

Isotype

IgG2a

Clonality

Monoclonal

Storage Temp

Store at -20В°C or lower. Aliquot to avoid repeated freezing and thawing.

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