Mouse anti Human TNFRSF6B monoclonal antibody, clone 330923 [Biotin]

Cat no: CABT-L168

Supplier: Creative Diagnostics

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Mouse Anti-Human TNFRSF6B monoclonal antibody for ELISA(Det). Human decoy receptor 3 (DcR3), also called TNFRSF6B, TR6 and M68, is a member of the TNF receptor superfamily. The cDNA of DcR3 encodes a 300 amino acid (aa) polypeptide with a putative 23 aa signal peptide. Like osteoprotegerin (OPG), DcR3 lacks a transmembrane sequence and is a secreted protein. DcR3 shares sequence identity with OPG , TNFRII and Fas. It was found to be expressed in a variety of different tissues and at high levels in many malignant tumors. Among TNF family members, DcR3 was shown to bind with Fas ligand (FasL) and LIGHT and inhibit FasL-and LIGHT-induced apoptosis. Thus, in addition to DcR1, DcR2 and OPG, DcR3 is another TNFR family molecule which modulates ligands that induce apoptosis. Overexpression of DcR3 might be a mechanism by which certain tumors escape immune-cytotoxic attack.

Catalogue number:	CABT-L168
Reactivities:	Human
Hosts:	Mouse
Conjugates:	Biotin
Clone:	330923
Gene:	8771
Target:	TNFRSF6B
Isotype:	IgG1
Clonality:	Monoclonal
Storage temp:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

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Mouse anti Human TNFRSF6B monoclonal antibody, clone 330923 [Biotin]

Cat no: CABT-L168

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