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Mouse Soluble receptor activator of nuclear factor-kB ligand (sRANKL) ELISA Kit

Mouse Soluble receptor activator of nuclear factor-kB ligand (sRANKL) ELISA Kit

Cat no: KTE70118

Supplier: Abbkine Scientific Co.Ltd.
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This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Catalogue number: KTE70118
Reactivities: Mouse
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: O35235
Gene: 21943
Additional info: Mouse Soluble receptor activator of nuclear factor-kB ligand (sRANKL) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse TNFSF11. No significant cross-reactivity or interference between Mouse TNFSF11 and analogues was observed.

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