Mouse Transmembrane protein 9B (TMEM9B) ELISA Kit

The intracellular signaling pathway by which TNF induces its pleiotropic actions is well-characterized and includes unique components, as well as modules shared with other signaling pathways. TMEM9B as an important component of TNF signaling and which is a module shared with the IL-1? and Toll-like receptor (TLR) pathways. is a glycosylated protein localized in membranes of the lysosome and partially in early endosomes. The expression of TMEM9B is required for the production of proinflammatory cytokines induced by TNF, IL-1?, and TLR ligands, but not for apoptotic cell death triggered by TNF or Fas ligand. TMEM9B is essential in TNF activation of both the NF-?B and MAPK pathways.TMEM9B is a key component of inflammatory signaling pathways and suggest that endosomal or lysosomal compartments regulate these pathways.

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SPECIFICATIONS

Catalog Number

KTE70161

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

56786

Accession

Q9JJR8

Additional Info

Mouse Transmembrane protein 9B (TMEM9B) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse TMEM9B. No significant cross-reactivity or interference between Mouse TMEM9B and analogues was observed.