Mouse Tumor necrosis factor receptor superfamily member 18 (TNFRSF18) ELISA Kit

GITR (glucocorticoid-induced tumor necrosis factor receptor) is a surface receptor molecule that has been shown to be involved in inhibiting the suppressive activity of T-regulatory cells and extending the survival of T-effector cells. In mouse models, GITR was initially noted to be selectively enriched on the surface of regulatory T cells, making this an attractive potential surface marker for these rare cells. However, subsequent studies revealed GITR to also be up-regulated on any activated T cells in humans, thus undermining its utility as a regulatory T cell marker.Members of the tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies, such as TNFRSF18, regulate diverse biologic functions, including cell proliferation, differentiation, and survival. For further background information on the TNF and TNFR superfamilies.

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SPECIFICATIONS

Catalog Number

KTE70125

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

21936

Accession

O35714

Additional Info

Mouse Tumor necrosis factor receptor superfamily member 18 (TNFRSF18) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse TNFRSF18. No significant cross-reactivity or interference between Mouse TNFRSF18 and analogues was observed.