MRP3 (L1010) pAb

MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps ex- pressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also me- diates the transport of the organic anion S-(2,4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired.

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SPECIFICATIONS

Catalog Number

BS3177

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 981-1030 of Human MRP3.

Species

MRP3 (L1010) pAb detects endogenous levels of MRP3 protein.

Dilutions

WB: 1:500~1:1000

Swiss Prot

O15438

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 170

Alternative Names

ABC 31 antibody \nABC31 antibody \nABCC 3 antibody \nABCC3 antibody \nATP binding cassette sub family C (CFTR/MRP) member 3 antibody \nATP binding cassette sub family C member 3 antibody \nATP-binding cassette sub-family C member 3 antibody \nCanalicular multispecific organic anion transporter 2 antibody \nCanicular multispecific organic anion transporter antibody \nCMOAT 2 antibody \nCMOAT2 antibody \nEST90757 antibody \nMLP 2 antibody \nMLP2 antibody \nMOAT D antibody \nMOAT-D antibody \nMOATD antibody \nMRP 3