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MS-275 (Entinostat, SNDX-275)

MS-275 (Entinostat, SNDX-275)

Cat no: M4693-15A

Supplier: United States Biological
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MS-275 is a synthetic benzamide derivative that inhibited partially purified human histone deacetylase (HDA) with an IC50 of 2uM and induced hyperacetylation of nuclear histones in tumor cell lines. MS-275 inhibited the proliferation of various human tumor cell lines such as A2780, Calu-3, HL-60, and K562 (IC50 values were 0.0415uM, 0.195uM, 0.212uM, and 0.589uM, respectively). MS-275 also inhibited the growth of human tumor xenografts in nude mouse. Solubility: Soluble in DMSO at 25mg/ml with slight warming; very poorly soluble in ethanol and water; maximum solubility in plain water is estimated to be about 10-20uM. buffers, serum, or other additives may increase or decrease the aqueous solubility. Melting Point: 216-218C Elemental Anaylsis: Calculated: C=67.01% H=5.36% N=14.88% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Catalogue number: M4693-15A
Size: 25mg
Form: Supplied as a white to off-white powder.
Purity: ~99%
References: 1. Saito, A., et al. "A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors." Proc. Natl. Acad. Sci. USA 96:4592-4597 (1999). 2. Lee, B.I., et al. "MS-275, a histone deacetylase inhibitor, selectively induces transforming growth factor beta type II receptor expression in human breast cancer cells." Cancer Res. 61:931-934 (2001). 3. Ey

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