DNA mismatch repair protein Msh2 (Msh2) is a component of the post-replicative DNA mismatch repair system (MMR). Msh2 forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA heli, Xenopus/Amphibian, and shield appro, Xenopus/Amphibian,imately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA.