Supplier:
Alomone Labs Ltd.Cat no: M-200
MT-7
The muscarinic receptors are widely distributed throughout the body, but are predominantly expressed within the parasympathetic nervous system and exert both excitatory and inhibitory control over central and peripheral tissues.
Muscarinic receptors participate in a number of physiological functions such as regulation of heart rate, muscle contraction, cognition, sensory processing and motor control. They also participate in learning and memory processing.
MT-7 is a 65 amino acid peptide toxin isolated from the Dendroaspis angusticeps (Eastern green mamba). It was first found to inhibit M1 muscarinic receptors stably transfected in CHO cells at very low concentrations (1-30 nM)6 and acts as a non-competitive antagonist by binding to an allosteric site.
MT-7 binding studies using a M1 and M3 chimera demonstrated that the high affinity of MT-7 towards M1 receptor is due to only three residues located in the 2nd and 3rd extracellular loops of the receptor7.
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SPECIFICATIONS
Catalog Number
M-200
Size
20 micro g
Purity
>98%
Concentration
1-100 nM.
Shipping Temp
Room Temperature
Molecular Weight
7475 Da.
SUPPLIER INFO
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