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MTEP (3-pyridine)

Cat no: 045049

MTEP (3-pyridine)

Potent and selective antagonist for mGluR5. 5-fold higher anxiolytic activity than MPEP. Antidepressant. Neuroprotective. Produces antiparkinsonian-like effects in rats.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: +4 degrees C\nStable for at least 2 years after receipt when stored at +4 degrees C.

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SPECIFICATIONS

Catalog Number

045049

Size

5mg

Purity

>98% (NMR)

References

Product Reference: \n?3--pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity: J. Med. Chem. 46 204 (2003)\n?Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling: A. Klodzinska, et al.; Neuropharmacology 47, 342 (2004) \n?Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP: P.M. Lea IV & A.I. Faden; CNS Drug Rev. 12, 149 (2006) \n?Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist: A. Palucha, et al.; Pharmacol. Biochem. Behav. 81, 901 (2005) \n?Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors: P.M.t. Lea, et al.; Br. J. Pharmacol. 145, 527 (2005) \n?MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats: K. Ossowska, et al.; Neuropharmacology 49, 447 (2005) \n?

Alternative Names

3-pyridine

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