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MTEP (3-pyridine)

Cat no: 045049


Supplier: United States Biological
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Potent and selective antagonist for mGluR5. 5-fold higher anxiolytic activity than MPEP. Antidepressant. Neuroprotective. Produces antiparkinsonian-like effects in rats. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: +4 degrees C Stable for at least 2 years after receipt when stored at +4 degrees C.
Catalogue number: 045049
Size: 5mg
Purity: >98% (NMR)
Alternative names: 3-pyridine
References: Product Reference: ?3--pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity: J. Med. Chem. 46 204 (2003) ?Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling: A. Klodzinska, et al.; Neuropharmacology 47, 342 (2004) ?Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP: P.M. Lea IV & A.I. Faden; CNS Drug Rev. 12, 149 (2006) ?Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist: A. Palucha, et al.; Pharmacol. Biochem. Behav. 81, 901 (2005) ?Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors: P.M.t. Lea, et al.; Br. J. Pharmacol. 145, 527 (2005) ?MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats: K. Ossowska, et al.; Neuropharmacology 49, 447 (2005) ?

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