
Supplier:
Alomone Labs Ltd.Cat no: STC-400
mu-Conotoxin PIIIA
mu-Conotoxin PIIIA is a 22 amino acid peptidyl toxin isolated from the Conus purpurascens (Purple cone) venom and belongs to the conotoxin M superfamily.
It reversibly blocks mammalian skeletal muscle voltage-gated Na\\+\\ channels (Nav1.4, IC50 of 44 nM), Type II (Nav1.2) and PN1 (Nav1.7) neuronal voltage-gated Na\\+\\ channels (IC50 of 640 nM) by binding to site I domain of the channel.
In addition, it blocks irreversibly amphibian muscle Na\\+\\ channels.
Ion Channel Modulators; Voltage - Gated Na\\+\\ Channel Blockers
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