MUSK (10A4) Antibody

Cat no: 252887

Supplier: ABBIOTEC

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Description
Additional Information

MuSK (Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron a, Xenopus/Amphibian,ons secrete a protein called agrin. This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.

Catalogue number:	252887
Reactivities:	Human
Applications:	Immunofluorescence, Immunohistochemistry
Size:	0.1 ml
Accession:	O15146
Antigen:	Purified recombinant e, Xenopus/Amphibian,tracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag e, Xenopus/Amphibian,pressed in HEK293 cell line.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	10A4
Additional info:	Muscle, skeletal receptor tyrosine-protein kinase; Muscle-specific tyrosine-protein kinase receptor; Muscle-specific kinase receptor; MUSK