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MUSK (10A4) Antibody
ABBIOTEC

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ABBIOTEC

Cat no: 252887

MUSK (10A4) Antibody

MuSK (Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron a, Xenopus/Amphibian,ons secrete a protein called agrin. This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.

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SPECIFICATIONS

Catalog Number

252887

Size

0.1 ml

Applications

IF, IHC

Reactivities

Hum

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant e, Xenopus/Amphibian,tracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag e, Xenopus/Amphibian,pressed in HEK293 cell line.

Isotype

Mouse IgG1

Accession

O15146

Clonality

10A4

Additional Info

Muscle, skeletal receptor tyrosine-protein kinase; Muscle-specific tyrosine-protein kinase receptor; Muscle-specific kinase receptor; MUSK

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