A metabolite of Imatinib, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL).
Synonym: N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide
Solubility:
Chloroform
Melting Point:
181-183C (dec.)
Method for Determining Identity:
Proton NMR (CDCl3) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions:
SiO2: Dichloromethane: Methanol: NH4OH; 4: 1: 0.1; Visualized with UV and ninhydrin; Rf=0.25.
Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards:
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