The N-myc gene belongs to a family of proto-oncogenes, including the highly related c-myc, N-myc, and L-myc genes, that encode transcription factors sharing many structural and biochemical functions. The structural motifs conserved between the MYC proteins include a basic helix-loop-helix domain and a leucine zipper domain involved in DNA-protein and protein-protein interactions, respectively. These motifs are also found in numerous transcription factors that control cell determination during diverse cell processes such as myogenesis, neurogenesis, and sex determination.
Applications:
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution:
Western Blot: 1:2000
Optimal dilutions to be determined by the researcher.
Positive Control:
HeLa cell lysate
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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