N4BP1 (Y415) Peptide

Cat no: BS3340P

Supplier: Bioworld Technology, Inc.

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Nedd4-binding partner-1 (N4BP1) has been identified as a protein interactor and a substrate of the homologous to E6AP C terminus (HECT) domain-containing E3 ubiquitin-protein ligase (E3), Nedd4. Here, we describe a previously unrecognized functional interaction between N4BP1 and Itch, a Nedd4 structurally related E3, which contains four WW domains, conferring substrate-binding activity. We show that N4BP1 association with the second WW domain (WW2) of Itch interferes with E3 binding to its substrates. In particular, we found that N4BP1 and p73alpha, a target of Itch-mediated ubiquitin/proteasome proteolysis, share the same binding site. By competing with p73alpha for binding to the WW2 domain, N4BP1 reduces the ability of Itch to recruit and ubiquitylate p73alpha and inhibits Itch autoubiquitylation activity both in in vitro and in vivo ubiquitylation assays.

Catalogue number:	BS3340P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	O75113
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide N4BP1 (Y415). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	NEDD4 binding protein 1; N4BP1; KIAA0615
Additional info:	This peptide can be used with studies using BS3340 N4BP1 (Y415) pAb.

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N4BP1 (Y415) Peptide

Cat no: BS3340P

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