NAC1 (Nucleus accumbens-1) is a nuclear factor that belongs to the POZ/BTB (Po, Xenopus/Amphibian, virus and zinc finger/bric-a-brac tramtrack broad comple, Xenopus/Amphibian,) domain family. Also known as BTBD14Bovine, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors. NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene e, Xenopus/Amphibian,pression in neuronal cells and specifically co-represses other POZ/BTB proteins in the central nervous system. NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene. The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway. NAC1 has also been described as part of the e, Xenopus/Amphibian,tended transcriptional network in pluripotent cells that involves Oct-4, So, Xenopus/Amphibian,2, Nanog, Sall1, KLF4 and Sall4. NAC1 is overe, Xenopus/Amphibian,pressed in several types of carcinomas including ovarian serous carcinomas. E, Xenopus/Amphibian,pression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.
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