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Products NAP2 (Neutrophil Activating Protein 2, CXCL7, C-X-C motif chemokine 7, PPBP, pro-platelet basic protein)
| Catalogue number: | N0023A |
| Size: | 2ug |
| Form: | Supplied as a lyophilized powder. No additives. |
| Purity: | (same/more than) 98% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified. |
| References: | 1. Relationship between neutrophil-binding affinity and suitability for infection imaging: comparison of (99m)Tc-labeled NAP-2 (CXCL-7) and 3 C-terminally truncated isoforms. Rennen HJ, Frielink C, Zaat SA, J Nucl Med 2004 Jul;45(7):1217-23 2. Chemotactic activity of human blood leukocytes in plasma treated with EDTA: chemoattraction of neutrophils about monocytes is mediated by the generation of NAP-2. Malawista SE, Van Damme J, de Boisfleury Chevance A, J Leukoc Biol 2002 Jul;72(1):175-82 3. The CXC chemokine NAP-2 mediates differential heterologous desensitization of neutrophil effector functions elicited by platelet-activating factor. Schwartzkopff F, Brandt E, Flad HD, J Interferon Cytokine Res 2002 Feb;22(2):257-67 4. Thrombin-activated human platelets release two NAP-2 variants that stimulate polymorphonuclear leukocytes. Piccardoni P, Evangelista V, de Gaetano G, Thromb Haemost 1996 Nov;76(5):780-5 5. Limited and defined truncation at the C terminus enhances receptor binding and degranulation activity of the neutrophil-activating peptide 2 (NAP-2). Comparison of native and recombinant NAP-2 variants. Ehlert JE, Petersen F, Gerdes J, J Biol Chem 1995 Mar 17;270(11):6338-44 6. Neutrophil-activating peptides NAP-2 and IL-8 bind to the same sites on neutrophils but interact in different ways. Discrepancies in binding affinities, receptor densities, and biological effects. Besemer J, J Immunol 1995 Jan 15;154(2):972-4. |
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