NBS1 Antibody

Cat no: 200163

Supplier: ABBIOTEC

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Description
Additional Information

Nijmegen breakage syndrome protein 1 (NBS1) is a component of the MRE11/RAD50/NBN (MRN) comple, Xenopus/Amphibian,, which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The comple, Xenopus/Amphibian, is involved in double-strand break (DSB) repair, DNA recombination,Mouse,aintenance of telomere integrity, cell cycle checkpoint control and meiosis. NBS1 modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. Defects in NBS1 are the cause of Nijmegen breakage syndrome, cancer predisposition, and anemia.

Catalogue number:	200163
Reactivities:	Human, Mouse, Rabbit, Xenopus/Amphibian
Applications:	Western Blot
Size:	0.1 mg
Accession:	O60934, NP_002476
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human NBS1.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Clonality:	ABT-1064
Additional info:	Nibrin; Nijmegen breakage syndrome protein 1; Cell cycle regulatory protein p95; NBN; NBS; NBS1; P95