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Nectin-2 (Poliovirus Receptor Related 2, CD112, HVEB, MPH, PRR2, PVRL2) (PE)

Cat no: 167685

Nectin-2 (Poliovirus Receptor Related 2, CD112, HVEB, MPH, PRR2, PVRL2) (PE)

Nectins are a small family of Ca2+-independent immunoglobulin (Ig)-like cell adhesion molecules (CAMs) that control cell adhesion, proliferation, and migration.1-3 Mouse Nectin-2 is a 70 to 78kD type I transmembrane glycoprotein that is found on a variety of cell types.4, 5\nThe extracellular domain of mouse Nectin-2 (amino acids 32-338) shares 72%, 77%, and 95% amino acid sequence identity with the extracellular domain in human, canine, and rat Nectin-2, respectively. Through its interaction with natural killer cell- and T cell-expressed DNAM-1, it also promotes lymphocyte cytotoxicity and cytokine secretion against both tumors and dendritic cells (DCs) expressing 6, 7. Nectin-2. the immune system eliminates DCs that are inefficient at antigen presentation. Nectin-2 is expressed on epithelium, endothelial cells, Sertoli cells, monocytes, dendritic cells, granulosa cells, mast cells, eosinophils, and fibroblasts.07. \n\nApplications: \nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.

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SPECIFICATIONS

Catalog Number

167685

Size

100Tests

Applications

FC

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a liquid in 0.5% BSA, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).

P Type

Mab

Purity

Purified by Protein A or G affinity chromatography.

Isotype

IgG

Additional Info

Recognizes mouse Nectin-2.

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