Home  >  Products  >  Nell2, Recombinant, Mouse, aa22-238, His-tag (Protein Kinase C-binding Protein NELL2, MEL91 Protein, NEL-like Protein 2, Mel91, A330108N19Rik, R75516)
Nell2, Recombinant, Mouse, aa22-238, His-tag (Protein Kinase C-binding Protein NELL2, MEL91 Protein, NEL-like Protein 2, Mel91, A330108N19Rik, R75516)

Nell2, Recombinant, Mouse, aa22-238, His-tag (Protein Kinase C-binding Protein NELL2, MEL91 Protein, NEL-like Protein 2, Mel91, A330108N19Rik, R75516)

Cat no: 149776

Supplier: United States Biological
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NELL2 is a neuron-specific thrombospondin-1-like extracellular protein containing six epidermal growth factor-like domains. It is highly expressed in the hippocampus in vivo and promotes survival of rat primary cultured neurons through activation of JNK and suppression of ERK. As ERK is required for the induction of hippocampal long term potentiation (LTP) and JNK appears to be inhibitory on LTP, it had been suggested that NELL2 may play a role in synaptic plasticity. More recently, NELL2 has been shown to promote differentiation of motor and sensory neurons and stimulates mitogenesis of dorsal root ganglia in chickens. Source: Recombinant protein corresponding to mouse NELL2, fused to His-tag at C-terminal expressed in E.coli. Molecular Weight: ~29kD Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: 149776
Size: 50ug
Form: Supplied as a liquid in 100mM sodium phosphate, 10mM Tris, 500mM sodium chloride, 25mM imidazole, 2mM magnesium chloride, 10% glycerol.
Purity: ~95%
References: 1. Matsuhashi S, Noji S, Koyama E, et al. New gene, nel, encoding a M(r) 93 K protein with EGF-like repeats is strongly expressed in neural tissues of early stage chick embryos. Dev. Dyn. 1995; 203:212-22. 2. Oyasu M, Kuroda S, Nakashita M, et al. Immunocytochemical localization of a neuron-specific thrombospondin-1-like protein, NELL2: light and electron microscopic studies in the rat brain. Mol. Brain Res. 2000; 76:151-60. 3. Aihara K, Kuroda S, Kanamaya N, et al. A neuron-specific EGF family protein, NELL2, promotes survival of neurons through mitogen-activated protein kinases. Mol. Brain Res. 2003; 116:86-93. 4. Rosenblum K, Futter M, Voss K, et al. The role of extracellular kinases I/II in late-phase long-term potentiation. J. Neurosci. 2002; 22:5432-41.

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