Nephrin Antibody

Cat no: 251170

Supplier: ABBIOTEC

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Description
Additional Information

Nephrin plays a role in the development or function of the kidney glomerular filtration barrier. Nephrin regulates glomerular vascular permeability, and anchors the podocyte slit diaphragm to the actin cytoskeleton. Nephrin interacts with CD2AP (via C-terminal domain). Nephrin plays a role in skeletal muscle formation through regulation of myoblast fusion. Defects in NPHS1 are the cause of nephrotic syndrome type 1 (NPHS1), also known as Finnish congenital nephrosis (CNF). NPHS1 is a renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation.

Catalogue number:	251170
Reactivities:	Human, Mouse, Porcine, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	O60500
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human nephrin.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Nephrin; Renal glomerulus-specific cell adhesion receptor; NPHS1; NPHN