NEUREXIN 1 (CT) (NRXN1, DKFZp313P2036, FLJ35941, Hs.22998, KIAA0578, Neurexin-1-alpha precursor, Neurexin-1-beta precursor, Neurexin I-alpha, Neurexin I-beta)

Neurexin 1 (NRXN1) is a transmembrane neuronal protein and member of the neurexin family, which act as cell adhesion molecules and receptors within the vertebrate nervous system.\nNRXN1 exists in many distinct isoforms, the majority of which encode the longer alpha-neurexins generated using an upstream promoter, whilst fewer encode the shorter beta-neurexins, generated using a downstream promoter. Alpha-neurexins have been shown to bind with high affinity to the neuronal protein neurexophilin, whilst neuroligin 1, enriched in synaptic plasma membranes, has been identified as a splice site-specific ligand for beta-neurexins.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:32000\nWestern Blot: 0.05-0.1ug/ml\nOptimal dilutions to be determined by the researcher.\n\nRecommended Secondary Antibodies:\nRabbit Anti Goat IgG (Fc) FITC, HRP\n\nRecommended Useful Reagents:\nHUMAN CEREBELLUM, LEFT TOTAL PROTEIN LYSATE\nHUMAN CEREBELLUM, RIGHT TOTAL PROTEIN LYSATE \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.\n\nPeptide Blocking:\nCorresponding peptide is available for Peptide Blocking studies. See N2110-04A-P. Antibody

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SPECIFICATIONS

Catalog Number

N2110-04A

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum, Mouse, Rat, Can

Form

Supplied as a liquid in TBS, pH 7.3, 0.02% sodium azide, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

Additional Info

Recognizes an epitope within the CT region of human Neurexin 1 in cerebellum cell lysates at ~150kD. Species crossreactivity: Expected to react with Mouse, rat, and canine.