Neurite Outgrowth Inhibitor A (NogoA)

The capacity of the adult mammalian central nervous system (CNS) to repair lesions by axonal regeneration is very limited. However, CNS axons can extend for long distances in peripheral nerve grafts. CNS white matter selectively inhibits axonal outgrowth. Several components of CNS white matter, NI35, NI250 (Nogo) and MAG, that inhibit axon extension have been described. Neurite outgrowth inhibitor Nogo, also known as ASY and RTN-X, is a member of the reticulon (Rtn) family. Research on Nogo may be important in finding ways to promote nerve regeneration after stroke or spinal cord injury. Nogo induces apoptosis in various cancer cells when overexpressed so it may act to suppress tumor development. The nogo gene encodes at least three major protein products (Nogo-A, -B and

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SPECIFICATIONS

Catalog Number

N2115-10

Size

100ug

Applications

IP, WB

Hosts

Rabbit

Reactivities

Rat

Form

Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

P Type

Pab

Purity

Purified by epitope affinity chromatography.

Additional Info

Specific for rat Nogo-A. On Western blots for rat brain homogenates, it identifies a band at ~190kD. The faint bands at lower molecular weights may represent the deglycosylated form(s) or degradation product(s) of rat Nogo-A. Reactivity has been confirmed with rat brain homogenates. Based on amino acid sequence homolog, cross-reactivity with\nhuman is expected.