Neurite Outgrowth Inhibitor Protein A, Rat (NogoA) (Control Peptide)

An 18-aa peptide in the middle region of the putative extracellular domain of rat Nogo-A .\n\nMany tissues such as muscle, skin, liver, and peripheral nerve, have remarkable ability to repair and regrow after injury. However, the CNS (brain and spinal cord) is limited in its ability to repair or regrowth causing permanent brain damage or paralyses. Most recently an inhibitory myelin protein, Nogo (Neurite outgrowth), has been cloned and characterized. It may help block the regeneration of the CNS. Nogo is the 4th member of reticulon (Rtn) family. There are three alternative isoforms of Nogo, designated Nogo-A (full length human protein 1192 aa; calculated mol wt 135kD; rat 1163 aa), an intermediate form Nogo-B (373 aa; ~37 K, lacks 186-1004 aa within the extracellular domain), and a shorter form Nogo-C (199 aa; ~25 K, similar to rat vp20 and foocen-s; lacks 186-1004 aa but which has a smaller, alternative N-terminal domain). Nogo-A has a putative extracellular domain of 1024aa, 2-3 TM domains, and a short C-terminus of 43aa. Nogo-A is localized to the CNS-myelin, and is highly expressed in oligodendorcytes but not by Schwann cells. Nogo-B and Nogo-C have been found in several non-neuronal tissues (skeletal muscle, kidney, skin, lung, and spleen), and it may be the 35-kD protein recognized by IN-1 antibody.

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SPECIFICATIONS

Catalog Number

N2116-21

Size

50ug

Form

Supplied as a liquid in PBS, pH 7.2

Purity

Highly purified

References

Chen MS et al (2000) Nature 403, 434-439; GrandPre T et al (2000) Nature 403; 439-444; Goldberg JL and Barres BA (2000) Nature 403; 369-370; Prinjha R et al (2000) Nature 403, 383-384; Tessier-Lavigne M and Goodman CS (2000) Science 287, 813-814; Nagase T et al (1998) DNA Res. 5, 355-364

Additional Info

The rat peptide sequence is highly conserved in human Nogo-A