NeuroD1, NT (NEUROD1, BHLHA3, NEUROD, Neurogenic differentiation factor 1, Class A basic helix-loop-helix protein 3) (PE)

NeuroD1 acts as a differentiation factor during neurogenesis. They are expressed transiently in a subset of neurons in the central and peripheral nervous systems at the time of their terminal differentiation. NeuroD1 is a basic helix-loop-helix (bHLH) protein contain 1 bHLH domain. NeuroD1 is a transcriptional activator, for efficient DNA binding it requires dimerization with another bHLH protein. It was reported that NeuroD1 involves heterodimerization with the ubiquitous bHLH protein E47, and regulates insulin gene expression by binding to a critical E-box motif on the insulin promoter. Defects in NEUROD1 causes maturity onset diabetes of the young type VI. MODY6 is a form of non-insulin-dependent diabetes mellitus (NIDDM) characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern blot1:100-500\nImmunohistochemistry: 1:50-100\nImmunofluorescence: 1:100\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze R-Phycoerythrin conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

038911-PE

Size

200ul

Applications

ELISA, IF, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to R-Phycoerythrin (R-PE).

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

Breslin, M.B., et al., J. Biol. Chem. 278(40):38991-38997 (2003).\nMalecki, M.T., et al., Acta Diabetol 40(2):109-111 (2003).\nCinek, O., et al., Diabetes Res. Clin. Pract. 60(1):49-56 (2003).\nYe, L., et al., Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19(6):484-487 (2002).\nKanatsuka, A., et al., Metab. Clin. Exp. 51(9):1161-1165 (2002).

Additional Info

Human

Alternative Names

NEUROD1, BHLHA3, NEUROD, Neurogenic differentiation factor 1, Class A basic helix-loop-helix protein 3