Neurofibromin, aa27-41 (NF1, WSS, NFNS, VRNF, NF, Neurofibromin 1, neurofibromatosis, type I, von Recklinghausen disease neurofibromin, Neurofibromatosis-Noonan syndrome, WATS, Watson Syndrome)

Neurofibromin is a product of the tumor suppressor gene, Neurofibromatosis type I. Neurofibromin is known to have GTPase activity that modulates the ras pathway. The absence of or alteration of the neurofibromin protein may lead to Neurofibromatosis disease. This protein has not been purified, therefore, most of the information regarding this protein has been deduced from homology analysis of its gene sequence.\n\nWestern Blot (1:500-1:2,000), showing a band-set at 200-240kD and 450kD, and Immunohistochemistry of frozen and paraffin sections (1:200-1:500). This antibody does not require antigen retrieval methods.

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SPECIFICATIONS

Catalog Number

N2150-02

Size

500ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Reed, N., and D.H. Gutmann. Tumorigenesis in neurofibromatosis: new insights and potential therapies. Trends Mol. Med. 7(4): 157-62, 2001. 2. Zhu, Y., and L.F. Parada. Neurofibromin, a tumor suppressor in the nervous system. Exp. Cell Res. 264(1): 19-28, 2001.

Additional Info

Specific for neurofibromin. Species crossreactivity: Reacts with human, mouse and rat neurofibromin.