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Neurokinin A (Substance K)

Cat no: N1255-25

Neurokinin A (Substance K)

Neurokinin A/Substance K represents a member of the tachykinin family of peptides. Neurokinin A, which arises by cleavage of the substance P precursor, occurs in neurons in the central and peripheral nervous systems, and is particularly numerous in the gastrointestinal tract. The biological actions of neurokinin A are similar to those of substance P, and include vasodilation and stimulation of smooth muscle contraction. \n\nApplications: \nSuitable for use in Immunofluorescence and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilutions:\nImmunohistochemistry (Frozen and paraffin sections): 1:400-1:800 (PAP).\nImmunofluorescence microscopy: 1:200-1:400 (using FITC) with overnight incubation at 4 degrees C.\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: \nFormalin-fixed paraffin sections of rat colon\n\nStorage and Stability: \nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

N1255-25

Size

50ul

Applications

IF, IHC

Hosts

Rabbit

Reactivities

Hum, Rat, Prc

Form

Supplied as a lyophilized powder. Reconstitute with 50ul sterile, ddH2O. Dilute further in 0.1M PBS, 1% BSA, 0.1% sodium azide.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Karila P et al: Projections and actions of tachykininergic, cholinergic, and serotoninergic neurones in the intestine of the Atlantic cod. Cell Tissue Res 291, 403-413 (1998). 2. Hauser-Kronberger et al: Neuropeptides in the human penis. An immunohistochemical study. J Andrology 15, 510-520 (1994). 3. Schmidt P et al: Substance P and Neurokinin A are codistributed and colocalized in the porcine gastrointestinal tract. Peptides 12, 963-973 (1991). 4. Schmidt et al.: Substance P and Neurokinin A are codistributed and colocalized in the porcine gastrointestinal tract. Peptides 12, 963-973 (1991). 5. Lundberg LM. Growth and degeneration of uterine innervation. An experimental study in the guinea pig. Thesis Lund 1988.

Additional Info

Recongnizes Neurokinin A. Absorption with 10-100ug NKA per ml diluted antiserum abolishes the staining, while substance P does not. Species Crossreactivity: human, porcine, rat and fish

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