Neuropeptide Y3 Receptor (NPY 3R)

Neuropeptide Y (NPY), a neuropeptide colocalized and abundantly released with the neurotransmitter norepinephrine in nervous system, synthesized by postnatal olfactory epithelium of sustentacular cells. It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. NPY a 97aa peptide in mouse, human (chr 7p15.1) and 98aa in rat has a mol. wt of 11kD. NPY shows sequence homology to Peptide YY (PYY) and over 50% homology in amino acid and nucleotide sequence to Pancreatic Polypeptide (PNP or PPY), all of these homologous peptides has a 36aa mature peptide characterized by a hairpin loop. \nNPY3R/ CXCR4/ LSTR/ Fusin/ Chemokine, a 359aa protein in mouse, rat and 352 in human (chr 2q21), it shows 21% identity to NPY1R, they may help in activation of inflammatory cells.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilutions:\nELISA: 0.5-1ug/ml; Control peptide can be used to coat ELISA plates at 1ug/ml. \nWestern Blot: 1-10ug/ml (ECL)\nOptimal dilutions to be determined by the researcher.\n\nRecommended Control Peptide:\nN2176-64B: Neuropeptide Y3 Receptor, Human, Control Peptide (NPY 3R)\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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