Neurotensin is a peptide neurotransmitter hormone produced from a 170 amino acid precursor protein, first isolated in 1973 from bovine hypothalamus. Neurotensin signaling is transmitted through three receptors; NTS1 and NTS2 are 7-transmembrane G-protein coupled receptors, and NTS3 is a type I membrane receptor with a large extra cellular domain.
Neurotensin synaptic transmission is terminated primarily by specific enzymatic cleavage of neurotensin by several peptidases. Neurotensin participates in the regulation of Hypophyseal Prolactin and Luteinizing Hormone (LH) secretion4�and has a pivotal role in the dopaminergic system regulation.
.Neurotensin is implicated in body temperature regulation, feeding behavior, locomotion regulation and pain transmission.
GPCR ligands are now part of our growing portfolio of GPCR related products, which also includes antibodies. Alomone Labs is pleased to offer Neurotensin�(#GPN-100), a biologically active synthetic peptide in convenient sizes and at attractive prices.
Protein Coupled Receptor Ligands; Neurotensin Receptor Ligands.
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