NFATC1, CT (NFATC1, NFAT2, NFATC, Nuclear factor of activated T-cells, cytoplasmic 1, NFAT transcription complex cytosolic component)

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\nImmunohistochemistry: 1:10-50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

038927

Size

200ul

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Liu, Y.J., et al. Obesity (Silver Spring) 18(12):2339-2346(2010)\nBailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)\nChen, C., et al. Biocell 34(2):57-63(2010)\nDavila, S., et al. Genes Immun. 11(3):232-238(2010)\nAmaral, F.R., et al. J. Oral Pathol. Med. 39(3):269-274(2010)

Additional Info

Human

Alternative Names

NFATC1, NFAT2, NFATC, Nuclear factor of activated T-cells, cytoplasmic 1, NFAT transcription complex cytosolic component