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NFKBIB (I-kappa-B-beta, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta)

Cat no: 030491

NFKBIB (I-kappa-B-beta, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta)

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.Tissue specificity: Expressed in all tissues examined.\n\nApplications:\nWestern Bloting: 1:500-1:2000.\nELISA: Suggested dilution 1:10000.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

030491

Size

100ul

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

Form

Ascites fluid, 0.03% sodium azide.

P Type

Mab

Purity

Ascites

Isotype

IgG1

References

1. Mol Cell Biol. 2004 Apr;24(7):3048-56.\n2. J Biol Chem. 2004 Oct 15;279(42):44030-8. \n3. J Bone Miner Res. 2009 Dec;24(12):2039-49.

Additional Info

Human

Alternative Names

IKBB; TRIP9; NFKBIB

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