NGF Receptor, Extracellular Domain, Recombinant, Human

NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75. Antibodies to NGF receptor may play a role in the identification of benign and malignant soft tissue lesions. The expression of human nerve growth factor \n(NGF) receptor in tumors and normal tissue was investigated with the use of a monoclonal antibody recently developed against that protein.\n\nSource:\nCHO cells\n\nBiological Activity:\nThe human NGF receptor extracellular domain is able to bind NGF.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Reconstitute to with sterile dH2O or buffer, aliquot and store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

N2050-15C

Size

10ug

Form

Supplied as a lyophilized powder in PBS, 20mM HEPES, pH 7.3./ 0.1M NaCl

Purity

Purified by lectin affinity chromatography.

References

1. Kahle, P., and Hertel, C. (1991). 2. The Journal of Biological Chemistry, Vol 267, No. 20, 13917-13923.\n3. Rabizadeh, S., Oh, J., Zhong, L., Yang, J., Bitler, C.M., Butcher, L. and Bredesen, D.E. (1993) Science, Vol 261, 245-248. 3. Baldwin, A.N., and Shooter, E.M. (1994) The Journal of Biological Chemistry, Vol 269, No. 15, 11456-11461.