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Nibrin (Nijmegen Breakage Syndrome Protein 1, NBS1, Cell Cycle Regulatory Protein p95, NBN, NBS, P95)

Cat no: N2498-02A

Nibrin (Nijmegen Breakage Syndrome Protein 1, NBS1, Cell Cycle Regulatory Protein p95, NBN, NBS, P95)

Nijmegen breakage syndrome 1 (NBS1), also known as nibrin, interacts with MRE11 and RAD50 to form a complex with nuclease activity which is involved in the initiation of nonhomologous end joining and homologous recombination. It is thought that NBS1 is involved in both DNA double-strand break repair and DNA damage-induced checkpoint activation. Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by hypersensitivity to ionizing radiation and cancer predisposition.\n\nApplications:\nSuitable for use in Immunoprecipitation and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nImmunoprecipitation: 1-4ug/mg\nWestern Blot: 1:1,000-1:10,000\nOptimal dilutions to be determined by the researcher.\n\nControl Peptide: N2498-02Q, Nibrin, Control Peptide, Human\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

N2498-02A

Size

100ug

Applications

IP, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in Tris-citrate/phosphate, pH 7.5, 0.09% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

Additional Info

Recognizes human NBS1.

Read more on Supplier website

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info
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