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Nicastrin

Cat no: N2525-07

Nicastrin

Nicastrin is a transmembrane glycoprotein containing an aminopeptidase domain/transferrin receptor superfamily domain. Nicastrin can form complexes with the presenilin proteins and is thought to modulate their activity. Presenilins are involved in the cleavage of b-amyloid precursor protein (b-APP), resulting in accumulation of b-amyloid peptides which are involved in the pathogenesis of Alzheimer

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SPECIFICATIONS

Catalog Number

N2525-07

Size

100ug

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.

P Type

Pab

Purity

Purified by epitope affinity chromatography.

Additional Info

Reacts with ~110kD (apparent molecular weight, the calculated molecular weight is ~80kD) human nicastrin. The molecular weight of membrane bound nicastrin is reported to be ~150kD. Reactivity is confirmed with human HEK293 cell lysates and mouse brain homogenates.

Read more on Supplier website

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info
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