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Nicotinic Receptor, beta 3

Cat no: N2565-32C

Nicotinic Receptor, beta 3

Acetylcholine receptors (AChRs) mediate synaptic transmission at the neuromuscular junction. The channel-linked AChR that mediates rapid, excitatory actions of acetylcholine is called nicotinic AChR (nAChR) because it can be activated by nicotine. The non-channel linked AChR that medicates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine. The nAChRs fall into two subclasses, the muscle-type and the neuronal-type. The muscle-type receptor is a pentameric glycoprotein of five membrane spanning subunits, (2 alpha 1

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SPECIFICATIONS

Catalog Number

N2565-32C

Size

5ml

Applications

WB

Hosts

Rabbit

Form

Supplied as a lyophilized powder. Reconstitution with 5.0 ml of TBS/Tween-20.

P Type

Pab

Purity

Purified by precipitation, dialysis and chromatography.

Isotype

IgG

Additional Info

Recognizes Nicotinic beta3 receptor (450-458) and the reactivity of Nicotinic beta3 receptor is ~85%. Does not react to Nicotinic alpha3 receptor, Nicotinic alpha4 receptor, Nicotinic alpha5 receptor, Nicotinic alpha7 receptor, Nicotinic beta2 receptor and Nicotinic beta4 receptor.

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