Nigericin Sodium

Nigericin sodium is not a typical salt. Since nigericin is an ionophore its very high affinity for monovalent cations such as Na+ and K+ means formation ofa salt is a facile possess occurring during purification under any but highly acidic conditions. Typically, the salts of polyether ionophores like the free acid are readily extracted into organic solvents. The sodium ion is stabilized within a polar pocket of the structure effectively making the salt and free acid different chemical moieties with the potential for differing pharmacology, a fact not readily appreciated in the literature. \n\nApperance: White powder\n\nSolubility: Soluble in DMSO, partially soluble in methanol and methanol, poor water solubility \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

N2566-90A

Size

5mg

Purity

~98%

References

1. Nigericin, a new crystalline antibiotic from an unidentified streptomyces. Harned R.L. et al., Antibiot. Chemother. 1951, 1, 594. 2. The structure of nigericin. Steinrauf L.K. et al., Biochem. Biophys. Res. Commun. 1968, 33, 29. 3. Nigericin-induced Na+/H+ and K+/H+ exchange in synaptosomes: effect on [3H]GABA release. Rodriguez R. & Sitges M., Neurochem. Res. 1996, 21, 889. 4. Nigericin inhibits accumulation of the steroidogenic acute regulatory protein but not steroidogenesis. King S.R. et al., Mol. Cell. Endocrinol. 2000, 166, 147. 5. Nigericin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. Chu C.Y. et al., J. Cell. Biochem. 2002, 85, 83. 6. Inhibitory effects of polyethers on human immunodeficiency virus replication. Nakamura M., Antimicrob. Ag. Chemother. 1992, 36, 492.