Used as an antihypertensive and antianginal. Nilvadipine is prescribed for patients with both hypertension and chronic major cerebral artery occlusion. In hypertensive patients with high risk of atherosclerosis, nilvadipine may protect LDL cholesterol from in vivo oxidation. Nilvadipine reduces infarction foci, improves cerebral microcirculation, but does not affect the systemic arterial blood pressure. Pathohistochemical studies have revealed that the volume of the infarction in the middle cerebral artery occlusion model could be decreased by nilvadipine. Although it is a dihydropyridine derivative, nilvadipine has several kinetic, dynamic, and therapeutic effects that are different from even those of the other voltage-dependent Ca2+ channel blockers belonging to the same class. Nilvadipine could easily be transmitted to the central nervous system. Moreover, vascular smooth muscles contracted by potassium were reported to be inhibited by nilvadipine. It antagonizes both L- and T-type Ca2+ channels and exerts an antioxidant effect that is reported to be greater than the effects of nimodipine, nicardipine, and amlodipine. It has also been reported that nilvadipine (but not amlodipine) increased striatal dopamine and DOPAC contents and protected against motor deficits in mice.
Melting Point:
144-146 degrees C
Solubility:
Chloroform
Method for Determining Identity:
Proton NMR Spectroscopic Analysis
TLC Conditions:
SiO2: Ethyl acetate: Hexane; 2:1;
Visualized with naked eyes and UV; Single spot; Rf=0.75:
Toxicity and Hazards:
Due to the potential danger associated with the use of some of United States Biological biochemicals, all products should be handled by qualified personnel only, trained in laboratory procedures, and familiar with potential hazards. Information is not available on the possible hazards of many experimental compounds. The absence of a warning must not be interpreted as indication of safety. The ultimate responsibility for the proper handling of any and all chemicals lies with the user. All goods sold by United States Biological carry the condition that liability for any injury, loss or damage whatsoever to persons or real property resulting from the handling of the said goods lies with the user. Acceptance of our goods binds the customer to these terms.
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